Over deze cursus
The importance of metal ions in chemistry and life is often underestimated. It is only in relatively recent years that the pivotal role of metal ions has become recognized, with breakthrough applications in innovative materials, medicinal chemistry, supramolecular chemistry and nanotechnology. This course deals with the chemistry of d-block elements in various oxidation states and the molecular structure, geometry, symmetry chirality and thermodynamic properties of the corresponding complexes. The magnetic and electronic properties of metal complexes are evaluated with ligand field theory. Dynamic aspects will be investigated with optical (absorption and luminescence) and magnetic resonance (NMR) spectroscopy. Special attention is paid to metal-ligand interactions with biologically relevant (macro)molecules and the metabolic transformation of metal complexes in biological systems, with focus on metal-protein and metal-nucleic acid interactions in relationship to inorganic medicinal chemistry. The use of metal complexes and coordination polymers in supramolecular chemistry and material sciences will also be treated. During the practicals of the course, you will have the chance to play with molecular building blocks by synthesising and characterising a mononuclear, oligonuclear and polynuclear metal--ligand coordination complexes, including organometallic-complexes, a sub-class of inorganic complexes that have a metal-carbon bond.
Leerresultaten
Recognize the importance of essential and non-essential metal ions in biological systems and material sciences
Reflect on the metal-ligand bond considering the d-block elements in various oxidation states
Deduce biologically-relevant metal ligand interactions via ligand replacement reactions
Understand the fluxional aspects of metal-coordinated ligands and their relevance for inorganic medicinal applications
Elaborate on the application of metal ions in coordination polymers and metal-organic frameworks
Predict the outcome of discrete polynuclear metal-organic complex synthesis and describe how the synthesis and final product can be analysed
Describe several approaches by which organometallic complexes can be made, how they can be conjugated to biological or bio-active molecules and how they interact with biomolecules like proteins and oligonucleotides
Apply laboratory class skills performing hands-on experiments (synthesis and characterization) and reflect on those via written report
Toetsing
- Written test with open and closed questions (50%)
- Assignment report (40%) Each week a small report will be written about the laboratory classes of that week. The average mark of the separate reports will be the final mark. Group size between 1 and 3. Failed or late submission of a report results in handing in the report at the next re-sit.
- Assignment oral presentation (10%) Presentation about an developed own experiment. Group size between 1 and 3. Based on the number of students this will be done individual or as a group (where every member will present). Based on individual performance, teachers can deviate from the group grade for individual students.
Voorkennis
ZSS06100 Laboratory Safety BNT20806 Bio-Inorganic Chemistry
Bronnen
- Weller, Inorganic Chemistry (8th preferred) and selected papers (hand outs)
Aanvullende informatie
- Neem contact op met een coordinator
- Niveaumaster
- Instructievormop de campus